Title : Vascular endothelial growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase.

Pub. Date : 2008 May

PMID : 18182045






2 Functional Relationships(s)
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1 Vascular endothelial growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase. Glutamic Acid vascular endothelial growth factor A Rattus norvegicus
2 Together, these findings indicate that VEGF has neuroprotective effects in rat spinal cord against chronic glutamate excitotoxicity by activating the PI3-K/Akt signal transduction pathway and also reinforce the hypothesis of the potential therapeutic effects of VEGF in the prevention of motoneuron degeneration in human ALS. Glutamic Acid vascular endothelial growth factor A Rattus norvegicus