Title : Modulation of Dickkopf-1 attenuates glucocorticoid induction of osteoblast apoptosis, adipocytic differentiation, and bone mass loss.

Pub. Date : 2008 Apr

PMID : 18174290






1 Functional Relationships(s)
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1 In this study, knockdown of DKK1 expression by end-capped phosphorothioate DKK1 antisense oligonucleotide (DKK1-AS) abrogated dexamethasone suppression of alkaline phosphatase activity and osteocalcin expression in MC3T3-E1 preosteoblasts. Dexamethasone bone gamma-carboxyglutamate protein Homo sapiens