Title : BDNF level in the rat prefrontal cortex increases following chronic but not acute treatment with duloxetine, a dual acting inhibitor of noradrenaline and serotonin re-uptake.

Pub. Date : 2008 May

PMID : 18172756






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1 We investigated the effects of acute and chronic treatment with Duloxetine, a new drug blocking the re-uptake of serotonin and noradrenaline (SNRI), on BDNF level in the prefrontal cortex, cerebrospinal fluid, plasma, and serum. Duloxetine Hydrochloride brain-derived neurotrophic factor Rattus norvegicus
2 In animals treated for 14 days with Duloxetine at 30 and 100 mg/kg, the total BDNF level increased significantly in the prefrontal cortex and CSF, but not in the plasma and serum. Duloxetine Hydrochloride brain-derived neurotrophic factor Rattus norvegicus
3 Using a specific antibody and Western blot we showed that the mature, but not the precursor, form of BDNF was significantly increased in the prefrontal cortex of rats treated for 14 days with Duloxetine at 30 mg/kg/day. Duloxetine Hydrochloride brain-derived neurotrophic factor Rattus norvegicus
4 CONCLUSIONS: Our results show a major finding that repeated, but not single, Duloxetine treatment increases the level of BDNF in the prefrontal cortex. Duloxetine Hydrochloride brain-derived neurotrophic factor Rattus norvegicus