Pub. Date : 2008 Feb
PMID : 18093689
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DEN administration caused greater increases in serum interleukin-6 (IL-6) concentration in males than it did in females. | Diethylnitrosamine | interleukin 6 | Mus musculus |
| 2 | DEN administration caused greater increases in serum interleukin-6 (IL-6) concentration in males than it did in females. | Diethylnitrosamine | interleukin 6 | Mus musculus |
| 3 | DEN exposure promoted production of IL-6 in Kupffer cells (KCs) in a manner dependent on the Toll-like receptor adaptor protein MyD88, ablation of which also protected male mice from DEN-induced hepatocarcinogenesis. | Diethylnitrosamine | interleukin 6 | Mus musculus |
| 4 | DEN exposure promoted production of IL-6 in Kupffer cells (KCs) in a manner dependent on the Toll-like receptor adaptor protein MyD88, ablation of which also protected male mice from DEN-induced hepatocarcinogenesis. | Diethylnitrosamine | interleukin 6 | Mus musculus |
| 5 | Estrogen inhibited secretion of IL-6 from KCs exposed to necrotic hepatocytes and reduced circulating concentrations of IL-6 in DEN-treated male mice. | Diethylnitrosamine | interleukin 6 | Mus musculus |