Pub. Date : 2007 Dec
PMID : 18088190
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Parthenolide sensitizes cells to X-ray-induced cell killing through inhibition of NF-kappaB and split-dose repair. | parthenolide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | We investigated whether parthenolide would enhance X-ray-induced cell killing in radiation resistant, NF-kappaB-activated CGL1 cells. | parthenolide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Treatment with 5 microM parthenolide for 48 to 72 h inhibited constitutive NF-kappaB binding and cell growth, reduced plating efficiency, and induced apoptosis through stabilization of p53 (TP53), induction of the pro-apoptosis protein BAX, and phosphorylation of BID. | parthenolide | nuclear factor kappa B subunit 1 | Homo sapiens |