Title : p53-dependent Chk1 phosphorylation is required for maintenance of prolonged G2 Arrest.

Pub. Date : 2007 Dec

PMID : 18088187






1 Functional Relationships(s)
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1 The pathway of Chk1 phosphorylation --> Cdc25A degradation --> inhibition of cyclin B1/Cdk1 activity --> G2 arrest is accordingly resistant to staurosporine and UCN-01 in p53+/+ cells. 7-hydroxystaurosporine cyclin dependent kinase 1 Homo sapiens