Pub. Date : 2008 Jul
PMID : 18083229
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bortezomib has been shown to exert inhibitory effects on NFkappaB activity. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Additionally, we show that the co-incubation of bortezomib with melphalan or doxorubicin reduces activation of NFkappaB. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | These data suggest that the drug-sensitizing effect of bortezomib on MM cells is due to inhibition of melphalan- and doxorubicin-induced activation of NFkappaB activity. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |