Pub. Date : 2008 Feb 2
PMID : 18083161
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-kappaB and Akt pathways. | Berberine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | This study focused on the suppressive effects of berberine on receptor activator of nuclear factor kappaB (NF-kappaB) ligand (RANKL)-induced osteoclastogenesis and survival. | Berberine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Berberine attenuated RANKL-induced activation of NF-kappaB through inhibiting phosphorylation at the activation loop of IkappaBalpha kinase beta, phosphorylation and degradation of IkappaBalpha, and NF-kappaB p65 nuclear translocation. | Berberine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Berberine attenuated RANKL-induced activation of NF-kappaB through inhibiting phosphorylation at the activation loop of IkappaBalpha kinase beta, phosphorylation and degradation of IkappaBalpha, and NF-kappaB p65 nuclear translocation. | Berberine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | These findings indicate that berberine inhibits osteoclast formation and survival through suppression of NF-kappaB and Akt activation and that both pathways in the osteoclast lineage are highly sensitive to berberine treatment. | Berberine | nuclear factor kappa B subunit 1 | Homo sapiens |