Title : Clinical impact of nucleophosmin mutations and Flt3 internal tandem duplications in patients older than 60 yr with acute myeloid leukaemia.

Pub. Date : 2008 Mar

PMID : 18081718






2 Functional Relationships(s)
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Protein Name
Organism
1 We can demonstrate a significant higher rate of CR comparing wildtype vs. NPM1 positive patients (40.5% for group 1 vs. 80.0% for group 2, P = 0.03) for patients receiving curative therapy. Chromium nucleophosmin 1 Homo sapiens
2 CONCLUSION: As elderly but medically fit patients with AML carrying a NPM1 mutation have a high CR rate, age itself should not be a barrier for induction treatment. Chromium nucleophosmin 1 Homo sapiens