Title : Celecoxib inhibits production of MMP and NO via down-regulation of NF-kappaB and JNK in a PGE2 independent manner in human articular chondrocytes.

Pub. Date : 2008 Jun

PMID : 18080123






2 Functional Relationships(s)
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1 The inhibitors of NF-kappaB, JNK and p38, but not ERK, decreased IL-1beta-enhanced MMP-1, MMP-3 and NO production, respectively, and 100 nM celecoxib down-regulated the phosphorylation of NF-kappaB and JNK but has no effect on either p38 or ERK. Celecoxib mitogen-activated protein kinase 1 Homo sapiens
2 Despite the COX-2 selectivity, celecoxib affects those productions via not PGE2 but NF-kappaB and JNK MAPK. Celecoxib mitogen-activated protein kinase 1 Homo sapiens