Pub. Date : 2008 Feb 15
PMID : 18079115
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of AMP-activated protein kinase sensitizes cancer cells to cisplatin-induced apoptosis via hyper-induction of p53. | Cisplatin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | Here we demonstrate that AMPK is rapidly activated by cisplatin in AGS and HCT116 cancer cells. | Cisplatin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | The inhibition of AMPK in those cells and in xenografts of HCT116 resulted in a remarkable increase in cisplatin-induced apoptosis, which was associated with hyper-induction of the tumor suppressor p53. | Cisplatin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 4 | Collectively, our data suggest that AMPK performs a pivotal function for protection against the cytotoxic effect of cisplatin, thereby implying that AMPK is one of the cellular factors determining the cellular sensitivity to cisplatin. | Cisplatin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 5 | Collectively, our data suggest that AMPK performs a pivotal function for protection against the cytotoxic effect of cisplatin, thereby implying that AMPK is one of the cellular factors determining the cellular sensitivity to cisplatin. | Cisplatin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 6 | Collectively, our data suggest that AMPK performs a pivotal function for protection against the cytotoxic effect of cisplatin, thereby implying that AMPK is one of the cellular factors determining the cellular sensitivity to cisplatin. | Cisplatin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 7 | Collectively, our data suggest that AMPK performs a pivotal function for protection against the cytotoxic effect of cisplatin, thereby implying that AMPK is one of the cellular factors determining the cellular sensitivity to cisplatin. | Cisplatin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |