Title : Inhibition of dipeptidyl peptidase-IV (DPP-IV) by atorvastatin.

Pub. Date : 2008 Jan 15

PMID : 18068977






4 Functional Relationships(s)
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1 Inhibition of dipeptidyl peptidase-IV (DPP-IV) by atorvastatin. Atorvastatin dipeptidyl peptidase 4 Homo sapiens
2 Inhibition of dipeptidyl peptidase-IV (DPP-IV) by atorvastatin. Atorvastatin dipeptidyl peptidase 4 Homo sapiens
3 In this report, we show that the hypolipidemic agent atorvastatin is a competitive inhibitor of porcine DPP-IV in vitro, with K(i)=57.8+/-2.3 microM. Atorvastatin dipeptidyl peptidase 4 Homo sapiens
4 These results may have implications in the development of novel DPP-IV inhibitors based on the use of atorvastatin as a lead compound for the treatment of type 2 diabetes. Atorvastatin dipeptidyl peptidase 4 Homo sapiens