Pub. Date : 2008 Mar
PMID : 18063724
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we examined the inhibition of alpha-methyl-d-glucopyranose transport by phlorizin and a new candidate drug, sergliflozin-A [(2-[4-methoxyphenyl]methyl)phenyl beta-d-glucopyranoside], in COS-7 cells expressing hSGLT1 and hSGLT2. | sergliflozin-A | solute carrier family 5 member 2 | Homo sapiens |
| 2 | Inhibition by sergliflozin-A was also competitive, with K(i) values of 1 muM in hSGLT1 and 20 nM in hSGLT2. | sergliflozin-A | solute carrier family 5 member 2 | Homo sapiens |
| 3 | In contrast, mutagenesis of the analogous Cys615 in hSGLT2 produced the opposite effect, a decrease in IC(50) for phlorizin and sergliflozin-A. | sergliflozin-A | solute carrier family 5 member 2 | Homo sapiens |