PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18063724-4 2008 In this study, we examined the inhibition of alpha-methyl-d-glucopyranose transport by phlorizin and a new candidate drug, sergliflozin-A [(2-[4-methoxyphenyl]methyl)phenyl beta-d-glucopyranoside], in COS-7 cells expressing hSGLT1 and hSGLT2. sergliflozin-A 123-137 solute carrier family 5 member 2 Homo sapiens 235-241 18063724-6 2008 Inhibition by sergliflozin-A was also competitive, with K(i) values of 1 muM in hSGLT1 and 20 nM in hSGLT2. sergliflozin-A 14-28 solute carrier family 5 member 2 Homo sapiens 100-106 18063724-10 2008 In contrast, mutagenesis of the analogous Cys615 in hSGLT2 produced the opposite effect, a decrease in IC(50) for phlorizin and sergliflozin-A. sergliflozin-A 128-142 solute carrier family 5 member 2 Homo sapiens 52-58