Title : Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus.

Pub. Date : 2008 May

PMID : 18061195






1 Functional Relationships(s)
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1 We sought to determine whether in vivo treatment with the HMG-CoA reductase inhibitor atorvastatin is able to upregulate the GTPCH-I, to recouple eNOS and to normalize endothelial dysfunction in an experimental model of diabetes mellitus. Atorvastatin nitric oxide synthase 3 Rattus norvegicus