Title : Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons.

Pub. Date : 2007 Dec

PMID : 18060037






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1 Here, we show that acute and chronic prolonged wakefulness in mice induced by modafinil treatment produced long-term potentiation (LTP) of glutamatergic synapses on hypocretin/orexin neurons in the lateral hypothalamus, a well-established arousal/wake-promoting center. Modafinil hypocretin Mus musculus