Title : Cigarette smoke inhibits macrophage sensing of Gram-negative bacteria and lipopolysaccharide: relative roles of nicotine and oxidant stress.

Pub. Date : 2008 Feb

PMID : 18059323






2 Functional Relationships(s)
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1 The effects of cigarette smoke extract on nitrite formation stimulated by LPS were unaffected by inhibition of nicotinic receptors with alpha-bungarotoxin (100 units ml(-1)). Nitrites toll-like receptor 4 Mus musculus
2 However, the effects of cigarette smoke extract on LPS-induced nitrite formation were mimicked by hydrogen peroxide and reversed by the anti-oxidants N-acetyl cysteine and glutathione. Nitrites toll-like receptor 4 Mus musculus