Title : 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography is a sensitive method for imaging the response of BRAF-dependent tumors to MEK inhibition.

Pub. Date : 2007 Dec 1

PMID : 18056475






2 Functional Relationships(s)
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1 3"-deoxy-3"-[18F]fluorothymidine positron emission tomography is a sensitive method for imaging the response of BRAF-dependent tumors to MEK inhibition. alovudine mitogen-activated protein kinase kinase 7 Homo sapiens
2 The profound G(1) arrest induced by MEK inhibition in BRAF mutant tumors is associated with a marked decline in thymidine uptake and is therefore potentially detectable in vivo by noninvasive 3"-deoxy-3"-[(18)F]fluorothymidine ([(18)F]FLT) positron emission tomography (PET) imaging. alovudine mitogen-activated protein kinase kinase 7 Homo sapiens