Pub. Date : 2008 Feb
PMID : 18054052
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The cannabinoid receptor subtype (CB1) antagonist rimonabant (SR141716) has been shown to decrease nicotine self-administration and attenuate nicotine-evoked dopamine release in the nucleus accumbens; effects that support recent findings on its clinical efficacy as a smoking cessation aid. | Nicotine | cannabinoid receptor 1 | Rattus norvegicus |
| 2 | The cannabinoid receptor subtype (CB1) antagonist rimonabant (SR141716) has been shown to decrease nicotine self-administration and attenuate nicotine-evoked dopamine release in the nucleus accumbens; effects that support recent findings on its clinical efficacy as a smoking cessation aid. | Nicotine | cannabinoid receptor 1 | Rattus norvegicus |
| 3 | The present experiments aim to advance our understanding on the role of CB1 receptors in rodent models of nicotine dependence. | Nicotine | cannabinoid receptor 1 | Rattus norvegicus |
| 4 | AM251, a selective antagonist at CB1 receptors dose-dependently (1, 3 and 10mg/kg IP) suppressed intravenous nicotine (0.03mg/kg per infusion) self-administration in rats during three successive days of pre-treatment. | Nicotine | cannabinoid receptor 1 | Rattus norvegicus |
| 5 | These preclinical findings support the use of rimonabant as a smoking cessation aid and highlight the CB1 receptor as a viable target to control intake of nicotine and prevent relapse. | Nicotine | cannabinoid receptor 1 | Rattus norvegicus |