Pub. Date : 2008 Jan 25
PMID : 18048359
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulatory effects of mammalian target of rapamycin-mediated signals in the generation of arsenic trioxide responses. | Arsenic Trioxide | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | In studies using primary hematopoietic progenitors from patients with acute myeloid leukemia, we found that pharmacological inhibition of mTOR enhances the suppressive effects of arsenic trioxide on leukemic progenitor colony formation. | Arsenic Trioxide | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | Altogether, these data provide evidence for a key regulatory role of the Akt/mTOR pathway in the generation of the effects of As(2)O(3), and suggest that targeting this signaling cascade may provide a novel therapeutic approach to enhance the anti-leukemic properties of As(2)O(3). | Arsenic Trioxide | mechanistic target of rapamycin kinase | Homo sapiens |