Pub. Date : 2008 Mar
PMID : 18042733
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Consistently, transcriptional activity of the BCRP promoter was induced 2- to 6-fold by 10(-8) to 10(-5) M progesterone in PRB-transfected cells. | Progesterone | RB transcriptional corepressor 1 | Homo sapiens |
| 2 | Progesterone had little effect on BCRP expression and activity and transcriptional activity of the BCRP promoter in PRA-transfected cells; however, cotransfection of PRA and PRB significantly decreased the progesterone-response compared with that in cells transfected with only PRB. | Progesterone | RB transcriptional corepressor 1 | Homo sapiens |
| 3 | Mutations in a novel progesterone response element (PRE) identified between -243 to -115 bp of the BCRP promoter region significantly attenuated the progesterone-response in PRB-transfected cells, and deletion of the PRE nearly completely abrogated the progesterone effect. | Progesterone | RB transcriptional corepressor 1 | Homo sapiens |
| 4 | Mutations in a novel progesterone response element (PRE) identified between -243 to -115 bp of the BCRP promoter region significantly attenuated the progesterone-response in PRB-transfected cells, and deletion of the PRE nearly completely abrogated the progesterone effect. | Progesterone | RB transcriptional corepressor 1 | Homo sapiens |
| 5 | Mutations in a novel progesterone response element (PRE) identified between -243 to -115 bp of the BCRP promoter region significantly attenuated the progesterone-response in PRB-transfected cells, and deletion of the PRE nearly completely abrogated the progesterone effect. | Progesterone | RB transcriptional corepressor 1 | Homo sapiens |
| 6 | Collectively, progesterone induces BCRP expression in BeWo cells via PRB but not PRA. | Progesterone | RB transcriptional corepressor 1 | Homo sapiens |