Title : Taxane's substituents at C3' affect its regioselective metabolism: different in vitro metabolism of cephalomannine and paclitaxel.

Pub. Date : 2008 Feb

PMID : 18039807






2 Functional Relationships(s)
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1 Compared with paclitaxel, the major hydroxylation site transferred from C6alpha to C4"", and the main metabolizing P450 changed from CYP2C8 to CYP3A4 for cephalomannine. cephalomannine cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Kinetic studies showed that CYP3A4 catalyzed cephalomannine more efficiently than paclitaxel due to an increased V(m). cephalomannine cytochrome P450 family 3 subfamily A member 4 Homo sapiens