Pub. Date : 2008 Jan 25
PMID : 18035049
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity. | Leucovorin | folylpolyglutamate synthase | Homo sapiens |
| 2 | We investigated the roles of folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH), which are the main enzymes involved in folate metabolism, in the effect of LV. | Leucovorin | folylpolyglutamate synthase | Homo sapiens |
| 3 | We investigated the roles of folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH), which are the main enzymes involved in folate metabolism, in the effect of LV. | Leucovorin | folylpolyglutamate synthase | Homo sapiens |
| 4 | Small-interfering RNA (siRNA) transfected into DLD-1 cells to downregulate FPGS reduced the basal level of reduced folate, the folate level after LV treatment, and the enhancement of 5-fluoro-2"-deoxyuridine (FdUrd)-induced cytotoxicity elicited by LV. | Leucovorin | folylpolyglutamate synthase | Homo sapiens |
| 5 | Small-interfering RNA (siRNA) transfected into DLD-1 cells to downregulate FPGS reduced the basal level of reduced folate, the folate level after LV treatment, and the enhancement of 5-fluoro-2"-deoxyuridine (FdUrd)-induced cytotoxicity elicited by LV. | Leucovorin | folylpolyglutamate synthase | Homo sapiens |
| 6 | These results suggest that FPGS and GGH expression levels in tumors are determinants of the efficacy of LV in enhancing the antitumor activity of 5-FU. | Leucovorin | folylpolyglutamate synthase | Homo sapiens |