Title : Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.

Pub. Date : 2008 Jan 1

PMID : 18024134






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 A hypothesis for the reduced hPNMT inhibitory potency of these compounds has been formed on the basis of molecular modeling and docking studies using the X-ray crystal structures of hPNMT co-crystallized with THIQ-type inhibitors and S-adenosyl-L-homocysteine as a template. 1,2,3,4-tetrahydroisoquinoline phenylethanolamine N-methyltransferase Homo sapiens
2 A hypothesis for the reduced hPNMT inhibitory potency of these compounds has been formed on the basis of molecular modeling and docking studies using the X-ray crystal structures of hPNMT co-crystallized with THIQ-type inhibitors and S-adenosyl-L-homocysteine as a template. 1,2,3,4-tetrahydroisoquinoline phenylethanolamine N-methyltransferase Homo sapiens