Title : Design, synthesis and biological evaluation of thrombin inhibitors based on a pyridine scaffold.

Pub. Date : 2007 Aug 21

PMID : 18019535






2 Functional Relationships(s)
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1 Design, synthesis and biological evaluation of thrombin inhibitors based on a pyridine scaffold. pyridine coagulation factor II, thrombin Homo sapiens
2 A Grignard exchange reaction was used to introduce various benzoyl substituents in position 4 of the pyridine ring, where they serve as P3 residues in binding to thrombin. pyridine coagulation factor II, thrombin Homo sapiens