Title : Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production.

Pub. Date : 2008 Apr

PMID : 18006877






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In a cell-free system, acrolein increased pro-hMMP9 cleavage and activity in concentrations (100-300 nM) found in sputum from subjects with COPD. Acrolein matrix metallopeptidase 9 Homo sapiens
2 Acrolein increased hMMP9 transcripts in human airway cells, which was inhibited by an MMP inhibitor, EGFR-neutralizing antibody, or a mitogen-activated protein kinase (MAPK) 3/2 inhibitor. Acrolein matrix metallopeptidase 9 Homo sapiens