Title : Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene.

Pub. Date : 2008 Jun

PMID : 17983653






2 Functional Relationships(s)
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1 AZD6244 potently down-regulated the levels of phospho-ERK1/2 and its downstream effector, p-p70S6K, in the MV4-11 and MOLM13 cells as measured by Western blot analysis. AZD 6244 ribosomal protein S6 kinase B1 Homo sapiens
2 Interestingly, when AZD6244 was combined with sunitinib, a FLT3 kinase inhibitor, growth inhibition and apoptosis of both MV4-11 and MOLM13 cells were synergistically enhanced in association with further down-regulation of phospho-ERK1/2 and p-p70S6K in these cells. AZD 6244 ribosomal protein S6 kinase B1 Homo sapiens