Pub. Date : 2007
PMID : 17982273
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanism of homocysteine-induced Rac1/NADPH oxidase activation in mesangial cells: role of guanine nucleotide exchange factor Vav2. | Homocysteine | Rac family small GTPase 1 | Rattus norvegicus |
| 2 | By small interfering RNA (siRNA), it was found that Rac1-siRNA attenuated Hcys-induced superoxide (O(2)(-)) production. | Homocysteine | Rac family small GTPase 1 | Rattus norvegicus |
| 3 | In Vav2-siRNA transfected RMCs, Hcys-induced Rac activity was blocked, which was accompanied by significant reduction of Hcys-induced O(2)(-). | Homocysteine | Rac family small GTPase 1 | Rattus norvegicus |
| 4 | This Vav2-siRNA also blocked Rac activation induced by C16-Ceramide (C16-Cer), an intermediate lipid product stimulated by Hcys. | Homocysteine | Rac family small GTPase 1 | Rattus norvegicus |
| 5 | These results suggest that Vav2 importantly contributes to Hcys-induced increase in Rac1 activity and consequent activation of NADPH oxidase in RMCs via ceramide-associated tyrosine phosphorylation. | Homocysteine | Rac family small GTPase 1 | Rattus norvegicus |