Pub. Date : 2007 Oct-Nov
PMID : 17980568
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We have reported that prostaglandin F2alpha (PGF2alpha) stimulates the synthesis of vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. | Dinoprost | mitogen-activated protein kinase 3 | Mus musculus |
2 | We have reported that prostaglandin F2alpha (PGF2alpha) stimulates the synthesis of vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. | Dinoprost | mitogen-activated protein kinase 3 | Mus musculus |
3 | PDGF-BB itself induced the phosphorylation of p44/p42 MAP kinase in these cells, and the effects of PDGF-BB and PGF2alpha on the phosphorylation of p44/p42 MAP kinase were additive. | Dinoprost | mitogen-activated protein kinase 3 | Mus musculus |
4 | These results strongly suggest that PGF2alpha-stimulated VEGF synthesis is amplified by PI3-kinase-mediating PDGF-BB signaling in osteoblasts, and that the effect is exerted at a point downstream from p44/p42 MAP kinase. | Dinoprost | mitogen-activated protein kinase 3 | Mus musculus |