PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17980568-1 2007 We have reported that prostaglandin F2alpha (PGF2alpha) stimulates the synthesis of vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Dinoprost 22-43 mitogen-activated protein kinase 3 Mus musculus 130-133 17980568-1 2007 We have reported that prostaglandin F2alpha (PGF2alpha) stimulates the synthesis of vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Dinoprost 45-54 mitogen-activated protein kinase 3 Mus musculus 130-133 17980568-8 2007 PDGF-BB itself induced the phosphorylation of p44/p42 MAP kinase in these cells, and the effects of PDGF-BB and PGF2alpha on the phosphorylation of p44/p42 MAP kinase were additive. Dinoprost 112-121 mitogen-activated protein kinase 3 Mus musculus 148-151 17980568-10 2007 These results strongly suggest that PGF2alpha-stimulated VEGF synthesis is amplified by PI3-kinase-mediating PDGF-BB signaling in osteoblasts, and that the effect is exerted at a point downstream from p44/p42 MAP kinase. Dinoprost 36-45 mitogen-activated protein kinase 3 Mus musculus 201-204