Title : In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system.

Pub. Date : 2008 Feb

PMID : 17962372






1 Functional Relationships(s)
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1 One drug and its metabolite, risperidone and 9-hydroxyrisperidone, of the 32 CNS compounds, and 6 of the 7 non-CNS drugs were determined to have positive efflux using ratio of ratios in MDR1-MDCK versus MDCK transwell assays. Paliperidone Palmitate ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus