Title : Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo.

Pub. Date : 2007 Nov

PMID : 17951543






4 Functional Relationships(s)
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1 In particular, Ikappa Balpha kinase beta (IKKbeta ), which can impair insulin signaling directly via serine phosphorylation of insulin receptor substrates (IRS) and/or indirectly via induction of transcription of proinflammatory mediators, has been implicated in free fatty acid (FFA)-induced insulin resistance in skeletal muscle. Fatty Acids, Nonesterified inhibitor of nuclear factor kappa B kinase subunit beta Rattus norvegicus
2 In particular, Ikappa Balpha kinase beta (IKKbeta ), which can impair insulin signaling directly via serine phosphorylation of insulin receptor substrates (IRS) and/or indirectly via induction of transcription of proinflammatory mediators, has been implicated in free fatty acid (FFA)-induced insulin resistance in skeletal muscle. Fatty Acids, Nonesterified inhibitor of nuclear factor kappa B kinase subunit beta Rattus norvegicus
3 These results demonstrate that inhibition of IKKbeta prevents FFA-induced impairment of hepatic insulin signaling, thus implicating IKKbeta as a causal mediator of hepatic insulin resistance caused by acutely elevated plasma FFA. Fatty Acids, Nonesterified inhibitor of nuclear factor kappa B kinase subunit beta Rattus norvegicus
4 These results demonstrate that inhibition of IKKbeta prevents FFA-induced impairment of hepatic insulin signaling, thus implicating IKKbeta as a causal mediator of hepatic insulin resistance caused by acutely elevated plasma FFA. Fatty Acids, Nonesterified inhibitor of nuclear factor kappa B kinase subunit beta Rattus norvegicus