Pub. Date : 2007 Dec
PMID : 17951033
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, in microsomes prepared from native human hepatocytes, only relatively specific competitors (inhibitors and/or substrates) of CYP1A2, CYP2C8, CYP2C9 and CYP3A4 reduced notably the degradation cyamemazine. | cyamemazine | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | The main routes of cyamemazine biotransformation are N-mono-demethylation (CYP1A2, CYP3A4 and CYP2C8) and mono-oxidation (either S-oxidized or hydroxylated derivatives which could not be discriminated because characterized by the same mass value) by CYP1A2 and CYP2C9. | cyamemazine | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |