Title : Ethanol promotes endoplasmic reticulum stress-induced neuronal death: involvement of oxidative stress.

Pub. Date : 2008 Mar

PMID : 17941056






1 Functional Relationships(s)
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1 Using SH-SY5Y neuroblastoma cells and primary cerebellar granule neurons as in vitro models, we demonstrated that exposure to ethanol alone had little effect on the expression of markers for ER stress; however, ethanol drastically enhanced the expression of GRP78, CHOP, ATF4, ATF6, and phosphorylated PERK and eIF2 alpha when induced by tunicamycin and thapsigargin. Tunicamycin heat shock protein family A (Hsp70) member 5 Homo sapiens