Title : Differential laminar effects of amphetamine on prefrontal parvalbumin interneurons.

Pub. Date : 2007 Nov 9

PMID : 17931790






3 Functional Relationships(s)
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1 The objective of this study was to characterize the effects of different amphetamine paradigms on the Fos activation of GABAergic interneurons that contain parvalbumin in the medial prefrontal cortex. Amphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 Although a sensitizing, repeated regimen of amphetamine induced Fos in all cortical layers, only layer V parvalbumin-immunolabeled cells were activated in the infralimbic and prelimbic cortices. Amphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
3 An acute amphetamine injection to naive rats was associated with an increase in Fos, but in parvalbumin-positive neurons of the prelimbic cortex, where it was preferentially induced in layer III. Amphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus