Pub. Date : 2007 Oct 11
PMID : 17928597
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | HER2 positivity was, however, associated with a significant benefit from paclitaxel. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 2 | The interaction between HER2 positivity and the addition of paclitaxel to the treatment was associated with a hazard ratio for recurrence of 0.59 (P=0.01). | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 3 | Patients with a HER2-positive breast cancer benefited from paclitaxel, regardless of estrogen-receptor status, but paclitaxel did not benefit patients with HER2-negative, estrogen-receptor-positive cancers. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 4 | CONCLUSIONS: The expression or amplification, or both, of HER2 by a breast cancer is associated with a benefit from the addition of paclitaxel after adjuvant treatment with doxorubicin (<60 mg per square meter) plus cyclophosphamide in node-positive breast cancer, regardless of estrogen-receptor status. | Paclitaxel | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |