Pub. Date : 2007 Dec
PMID : 17927985
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NF-kappaB activated by ER calcium release inhibits Abeta-mediated expression of CHOP protein: enhancement by AD-linked mutant presenilin 1. | Calcium | DNA damage inducible transcript 3 | Homo sapiens |
| 2 | Because both CHOP and NF-kappaB are activated by increased intracellular calcium and stress, yet have diametrically opposite effects on neuronal vulnerability, we sought to examine this interaction in greater detail. | Calcium | DNA damage inducible transcript 3 | Homo sapiens |
| 3 | We observed that IP3-mediated calcium release from ER, stimulated by Abeta exposure, mediated both CHOP expression and NF-kappaB DNA binding activity. | Calcium | DNA damage inducible transcript 3 | Homo sapiens |
| 4 | The enhanced release of calcium from IP3-mediated ER stores in mPS1 neurons stimulated increased NF-kappaB compared to normal neurons, which inhibited CHOP expression. | Calcium | DNA damage inducible transcript 3 | Homo sapiens |