Pub. Date : 2007 Dec 7
PMID : 17925407
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we demonstrate that some of the plasma VWF multimers contain surface-exposed free thiols. | Sulfhydryl Compounds | von Willebrand factor | Homo sapiens |
| 2 | The shear-induced thiol-disulfide exchange increases VWF binding to platelets. | Sulfhydryl Compounds | von Willebrand factor | Homo sapiens |
| 3 | The thiol-disulfide exchange involves some or all of nine cysteine residues (Cys(889), Cys(898), Cys(2448), Cys(2451), Cys(2490), Cys(2491), Cys(2453), Cys(2528), and Cys(2533)) in the D3 and C domains as determined by mass spectrometry of the tryptic VWF peptides. | Sulfhydryl Compounds | von Willebrand factor | Homo sapiens |
| 4 | These results suggest that the thiol-disulfide state may serve as an important structural determinant of VWF adhesion activity and can be modified by fluid shear stress. | Sulfhydryl Compounds | von Willebrand factor | Homo sapiens |