Title : Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism.

Pub. Date : 2008 Aug

PMID : 17923851






1 Functional Relationships(s)
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1 In healthy white subjects, CYP2C8*3 and the two novel haplotypes significantly influenced repaglinide pharmacokinetics in SLCO1B1c.521T/C heterozygous individuals: haplotype B was associated with reduced and haplotype C with increased repaglinide AUC (0-infinity). repaglinide solute carrier organic anion transporter family member 1B1 Homo sapiens