Title : CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats.

Pub. Date : 2007 Oct 23

PMID : 17921249






1 Functional Relationships(s)
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1 We demonstrate one mechanism for both the anxiety-like symptoms of withdrawal and excessive nicotine intake observed after abstinence, through recruitment of the extrahypothalamic stress peptide corticotropin-releasing factor (CRF) system and activation of CRF(1) receptors. Nicotine corticotropin releasing hormone Rattus norvegicus