Title : Decreased withdrawal symptoms but normal tolerance to nicotine in mice null for the alpha7 nicotinic acetylcholine receptor subunit.

Pub. Date : 2007 Dec

PMID : 17920082






5 Functional Relationships(s)
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1 The alpha7 subunit of the neuronal nicotinic acetylcholine receptor (nAChR) is highly expressed in the brain, and has been suspected to play a major role in nicotine addiction. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 The alpha7 subunit of the neuronal nicotinic acetylcholine receptor (nAChR) is highly expressed in the brain, and has been suspected to play a major role in nicotine addiction. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
3 The alpha7 subunit of the neuronal nicotinic acetylcholine receptor (nAChR) is highly expressed in the brain, and has been suspected to play a major role in nicotine addiction. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
4 In alpha7 -/- mice, the somatic effects of MEC-precipitated nicotine withdrawal were significantly reduced. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
5 Our results point to the alpha7 subunit as one of the players in nicotine withdrawal, but not in nicotine tolerance or basal anxiety-like behavior. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus