Pub. Date : 2007 Nov
PMID : 17919187
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | As SREBP-1c is also expressed in beta cells, we hypothesized that activation of SREBP-1c could be a part of the mechanism by which saturated fatty acids induce beta-cell lipotoxicity. | Fatty Acids | sterol regulatory element binding transcription factor 1 | Mus musculus |
| 2 | As SREBP-1c is also expressed in beta cells, we hypothesized that activation of SREBP-1c could be a part of the mechanism by which saturated fatty acids induce beta-cell lipotoxicity. | Fatty Acids | sterol regulatory element binding transcription factor 1 | Mus musculus |
| 3 | Saturated fatty acids, such as palmitic acid (PA), impair insulin secretion through SREBP-1c activation, whereas polyunsaturated fatty acids including eicosapentaenoic acid (EPA) restore PA-suppressed insulin secretion through suppression of SREBP-1c. | Fatty Acids | sterol regulatory element binding transcription factor 1 | Mus musculus |