Title : Salicylate blocks lipolytic actions of tumor necrosis factor-alpha in primary rat adipocytes.

Pub. Date : 2008 Jan

PMID : 17911533






6 Functional Relationships(s)
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1 Salicylate blocks lipolytic actions of tumor necrosis factor-alpha in primary rat adipocytes. Salicylates tumor necrosis factor Rattus norvegicus
2 To elucidate the cellular basis of this action, we show that salicylate suppresses TNF-alpha-induced extracellular signal-related kinase activation and intracellular cAMP elevation, two early events during the lipolysis response to TNF-alpha. Salicylates tumor necrosis factor Rattus norvegicus
3 To elucidate the cellular basis of this action, we show that salicylate suppresses TNF-alpha-induced extracellular signal-related kinase activation and intracellular cAMP elevation, two early events during the lipolysis response to TNF-alpha. Salicylates tumor necrosis factor Rattus norvegicus
4 TNF-alpha down-regulates perilipin but promotes its phosphorylation during lipolysis stimulation; these actions are efficiently reversed by salicylate. Salicylates tumor necrosis factor Rattus norvegicus
5 Salicylate slightly reduces basal but completely inhibits TNF-alpha-liberated lipase activity. Salicylates tumor necrosis factor Rattus norvegicus
6 These results provide novel evidence that salicylate directly blocks TNF-alpha-mediated FFA efflux from adipocytes, hence reducing plasma FFA levels and increasing insulin sensitivity. Salicylates tumor necrosis factor Rattus norvegicus