Pub. Date : 2008 Jan
PMID : 17911533
6 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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1 | Salicylate blocks lipolytic actions of tumor necrosis factor-alpha in primary rat adipocytes. | Salicylates | tumor necrosis factor | Rattus norvegicus | ||
2 | To elucidate the cellular basis of this action, we show that salicylate suppresses TNF-alpha-induced extracellular signal-related kinase activation and intracellular cAMP elevation, two early events during the lipolysis response to TNF-alpha. | Salicylates | tumor necrosis factor | Rattus norvegicus | ||
3 | To elucidate the cellular basis of this action, we show that salicylate suppresses TNF-alpha-induced extracellular signal-related kinase activation and intracellular cAMP elevation, two early events during the lipolysis response to TNF-alpha. | Salicylates | tumor necrosis factor | Rattus norvegicus | ||
4 | TNF-alpha down-regulates perilipin but promotes its phosphorylation during lipolysis stimulation; these actions are efficiently reversed by salicylate. | Salicylates | tumor necrosis factor | Rattus norvegicus | ||
5 | Salicylate slightly reduces basal but completely inhibits TNF-alpha-liberated lipase activity. | Salicylates | tumor necrosis factor | Rattus norvegicus | ||
6 | These results provide novel evidence that salicylate directly blocks TNF-alpha-mediated FFA efflux from adipocytes, hence reducing plasma FFA levels and increasing insulin sensitivity. | Salicylates | tumor necrosis factor | Rattus norvegicus |