Pub. Date : 2008 Jan
PMID : 17908921
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of CYP2A6 protein expression by skatole, indole, and testicular steroids in primary cultured pig hepatocytes. | Skatole | cytochrome P450 family 2 subfamily A member 19 | Sus scrofa |
| 2 | CYP2A6 is one of the enzymes involved in the hepatic metabolism of a naturally produced compound, skatole, in the pig. | Skatole | cytochrome P450 family 2 subfamily A member 19 | Sus scrofa |
| 3 | Low CYP2A6 activity has been linked to excessive accumulation of skatole in pig adipose tissue and development of the phenomenon "boar taint." | Skatole | cytochrome P450 family 2 subfamily A member 19 | Sus scrofa |
| 4 | The study has also examined whether CYP2A6 expression can be modulated by the boar taint compounds skatole and indole. | Skatole | cytochrome P450 family 2 subfamily A member 19 | Sus scrofa |
| 5 | In contrast to androstenone, skatole and indole (final concentrations, 1, 10, and 100 nM) had a stimulatory effect on CYP2A6 expression. | Skatole | cytochrome P450 family 2 subfamily A member 19 | Sus scrofa |
| 6 | The hormonal modulation of CYP2A6 expression might contribute to gender-related differences in pig hepatic CYP2A6 activity and skatole accumulation in pig adipose tissue. | Skatole | cytochrome P450 family 2 subfamily A member 19 | Sus scrofa |