PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17908921-0 2008 Regulation of CYP2A6 protein expression by skatole, indole, and testicular steroids in primary cultured pig hepatocytes. Skatole 43-50 cytochrome P450 family 2 subfamily A member 19 Sus scrofa 14-20 17908921-1 2008 CYP2A6 is one of the enzymes involved in the hepatic metabolism of a naturally produced compound, skatole, in the pig. Skatole 98-105 cytochrome P450 family 2 subfamily A member 19 Sus scrofa 0-6 17908921-2 2008 Low CYP2A6 activity has been linked to excessive accumulation of skatole in pig adipose tissue and development of the phenomenon "boar taint." Skatole 65-72 cytochrome P450 family 2 subfamily A member 19 Sus scrofa 4-10 17908921-5 2008 The study has also examined whether CYP2A6 expression can be modulated by the boar taint compounds skatole and indole. Skatole 99-106 cytochrome P450 family 2 subfamily A member 19 Sus scrofa 36-42 17908921-7 2008 In contrast to androstenone, skatole and indole (final concentrations, 1, 10, and 100 nM) had a stimulatory effect on CYP2A6 expression. Skatole 29-36 cytochrome P450 family 2 subfamily A member 19 Sus scrofa 118-124 17908921-11 2008 The hormonal modulation of CYP2A6 expression might contribute to gender-related differences in pig hepatic CYP2A6 activity and skatole accumulation in pig adipose tissue. Skatole 127-134 cytochrome P450 family 2 subfamily A member 19 Sus scrofa 27-33