Title : Arsenic salt-induced DNA damage and expression of mutant p53 and COX-2 proteins in SV-40 immortalized human uroepithelial cells.

Pub. Date : 2007 Nov

PMID : 17906315






2 Functional Relationships(s)
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1 Similarly, sodium arsenite stimulated a concentration-dependent increase in COX-2 expression. sodium arsenite prostaglandin-endoperoxide synthase 2 Homo sapiens
2 In conclusion, this study demonstrated that sodium arsenite is genotoxic to uroepithelial cells in vitro, and that it will induce expression of mutant p53 and COX-2 proteins, indicating a possible key event in carcinogenesis. sodium arsenite prostaglandin-endoperoxide synthase 2 Homo sapiens