Pub. Date : 2008 Jan 15
PMID : 17893873
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | c-Abl activates p38 MAPK independently of its tyrosine kinase activity: Implications in cisplatin-based therapy. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | Activation of p38 MAPK is a critical requisite for the therapeutics activity of the antitumor agent cisplatin. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | In this sense, a growing body of evidences supports the role of c-Abl as a major determinant of p38 MAPK activation, especially in response to genotoxic stress when triggered by cisplatin. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 4 | Here, we demonstrate that p38 MAPK activation in response to cisplatin does not require the tyrosine kinase activity of c-Abl. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |