Title : An altered fibronectin matrix induces anoikis of human squamous cell carcinoma cells by suppressing integrin alpha v levels and phosphorylation of FAK and ERK.

Pub. Date : 2007 Dec

PMID : 17879163






1 Functional Relationships(s)
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1 These findings provide evidence that mutations in the high-affinity heparin-binding domain in association with the V region of fibronectin, or altered fibronectin matrices, induce anoikis in human SCC cells by modulating integrin alpha v-mediated phosphorylation of FAK and ERK. Heparin mitogen-activated protein kinase 1 Homo sapiens