Title : Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene.

Pub. Date : 2007 Nov

PMID : 17875939






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Knockdown of either PXR or Msx2 attenuated the effect of MK4 on osteoblastic differentiation. menatetrenone nuclear receptor subfamily 1 group I member 2 Homo sapiens
2 Thus, the present study suggests that Msx2 is a target gene for PXR activated by vitamin K and suggests that the osteoprotective action of MK4 in the human mediates, at least in part, a genomic pathway of vitamin K signaling. menatetrenone nuclear receptor subfamily 1 group I member 2 Homo sapiens