Pub. Date : 2007 Aug
PMID : 17867559
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A novel effect of lobeline on vascular smooth muscle cell: inhibition of proliferation induced by endothelin-1. | Lobeline | endothelin 1 | Homo sapiens |
| 2 | Lobelia chinensis Lour, a traditional Chinese herb whose active ingredient is the alkaloid lobeline, demonstrated to antagonize the bioactive effect of endothelin-1 (ET-1) and prevent the proliferation of vascular smooth muscle cells (VSMCs) in hyperlipidemic rats. | Lobeline | endothelin 1 | Homo sapiens |
| 3 | Lobelia chinensis Lour, a traditional Chinese herb whose active ingredient is the alkaloid lobeline, demonstrated to antagonize the bioactive effect of endothelin-1 (ET-1) and prevent the proliferation of vascular smooth muscle cells (VSMCs) in hyperlipidemic rats. | Lobeline | endothelin 1 | Homo sapiens |
| 4 | The objective of the present study was to determine the effects of lobeline on proliferation of cultured human umbilical VSMCs induced by ET-1. | Lobeline | endothelin 1 | Homo sapiens |
| 5 | The results showed that the increased cell numbers and enhanced [3H]thymidine incorporation induced by ET-1 were inhibited and the transition of cells from static phase (G0/G1) to DNA synthesis (S) and mitotic phase (G2/M) was held back by lobeline in a concentration-dependent manner. | Lobeline | endothelin 1 | Homo sapiens |
| 6 | Lobeline inhibited the proliferation of human umbilical VSMCs induced by ET-1 in a dose-dependent manner and the anti-proliferative effect was involved in the reduce of increased [Ca2+]i, rather than nonspecific cytotoxicity. | Lobeline | endothelin 1 | Homo sapiens |